Kim DH, et al. - Given that periarticular injection (PAI) in multimodal analgesic pathways for knee arthroplasty may be augmented by motor-sparing peripheral nerve blocks, such as the infiltration between the popliteal artery and capsule of the posterior knee (IPACK) and the adductor canal block (ACB), researchers investigated whether the addition of ACB and IPACK to PAI would reduce pain on ambulation on postoperative day 1 vs PAI alone in this triple-blinded randomized controlled trial. Participants were 86 patients undergoing unilateral total knee arthroplasty. Either a PAI (control group, n = 43) or an IPACK with an ACB and modified PAI (intervention group, n = 43) was administered to patients. Significantly improved analgesia and attenuated opioid use post-total knee arthroplasty were achieved with the addition of IPACK and ACB to PAI vs PAI alone. The use of IPACK and ACB within a multimodal analgesic pathway is strongly supported in this study.