Estévez–López F, et al. – The physicians performed this study to identify subgroups in terms of adaptation to fibromyalgia (FM) and to analyze differences in FM severity between these subgroups. In investigations, heterogeneity of FM was shown by five clinically meaningful profiles of modifiable factors that were associated with FM severity. It was important to examine whether these profiles were associated with FM prognosis and the effectiveness of interventions, which would enhance the development of customized interventions based on adaptation profiles in FM.