ADAPT-2: A randomized clinical trial to reduce intraoperative EEG suppression in older surgical patients undergoing major noncardiac surgery
Anesthesia & Analgesia Sep 19, 2020
Tang CJ, Jin Z, Sands L, et al. - Researchers conducted this exploratory, single-center, randomized clinical trial including 204 patients with a mean age of 72 ± 5 years who were undergoing elective noncardiac surgery in order to ascertain if monitoring the brain using a processed EEG monitor reduced EEG suppression and subsequent postoperative delirium. The use of processed EEG to maintain the Patient State Index (PSI) > 35 was linked with less time spent in intraoperative EEG suppression. A greater percent of surgical time spent in EEG suppression was noted in correlation to preoperative cognitive impairment. Based on findings they suggest conducting a larger prospective cohort study including more cognitively vulnerable patients to show if an intervention to reduce EEG suppression is efficacious in lowering postoperative delirium.
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