Roy S, et al. - By analyzing retrospectively identified cases of biopsy-proven acute tubulointerstitial nephritis (AIN) that were seen at a single UK tertiary paediatric centre, researchers defined the range of AIN in their caseload, key features as well as response to therapy, with the purpose of informing paediatric nephrology practice. They studied 10 cases, with age ranged from 6–16 years, and Male:Female ratio 1:9. The participants received the final diagnoses of tubulointerstitial nephritis and uveitis syndrome (TINU; n = 6), idiopathic (n = 2), sarcoidosis (n = 1), and there was 1 child with Streptococcal disease. The median presenting plasma creatinine was measured to be 303 μmol/l. Treatment of 8 cases comprised immunosuppressive therapy with intravenous methylprednisolone (approximately 10 mg/kg for 3–5 days) and/or oral prednisolone (1–2 mg/kg initially, decreasing over 7–28 days). At last follow-up (median 18.5 months), the median creatinine and median eGFR (estimated glomerular filtration rate) was 71 μmol/l and 80 ml/min/1.73m², respectively. This investigation represents the only modern UK case series of biopsy-proven AIN in children. Findings revealed a high proportion of TINU in this population. Renal function improved with the treatment, however, an eGFR < 90 ml/min/1.73m² was detected in 7/10 patients at last follow-up. A standardized investigative work-up was suggested and long-term follow-up was advised by the experts.