Conroy AL, et al. - Researchers assessed the prevalence of acute kidney injury (AKI) at admission in pediatric severe malaria and examined the connection between AKI and clinical and renal recovery, as well as long-term neurocognitive functioning. For this prospective cohort study, Ugandan children with cerebral malaria (CM, n= 60) and severe malaria anemia (SMA, n=219) or community children (CC, n=173) between 1.5 and 12 years of age were recruited. Data revealed that AKI's overall prevalence was 35.1%, from 25.1% in SMA to 43.5% in CM. There was a strong correlation between AKI with child mortality, with more than 60% of deaths seen in children with AKI. A link between AKI and persistent neurologic deficits in CM children and long-term neurocognitive impairment in CM and SMA children was also seen. In addition, this research suggests that CKD is associated with AKI in children with severe malaria. Together, the outcomes show that AKI is a commonly seen complication of severe malaria linked to major long-term adverse health outcomes in African children.