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Acute kidney injury in patients hospitalised with COVID-19 from the ISARIC WHO CCP-UK Study: A prospective, multicenter cohort study

Nephrology Dialysis Transplantation Oct 22, 2021

Sullivan MK, Lees JS, Drake TM, et al. - A prospective multicentre cohort study of adults hospitalised with COVID-19 to examine if in these patients, risk factors for AKI would include co-morbidities and non-white race.

  • Among a total of 85,687 patients, acute kidney replacement therapy (KRT) was administered in 2,198 (2.6%) patients.

  • Biochemistry data were available for 41,294 patients; 13,000 of these (31.5%) had biochemical AKI.

  • Chronic kidney disease, male gender and black race were identified to be the main risk factors for KRT.

  • For biochemical AKI, following were the main risk factors: admission respiratory rate > 30 breaths per minute, CKD and black race.

  • Overall findings suggest a common occurrence of AKI in adults hospitalized with COVID-19 and its association with an increased risk of mortality.

  • Although, there has been a decline in the rates of AKI from the early months of the pandemic, close monitoring of kidney function and fluid status should be done in high-risk patients.

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