Mortimer B, Naganur VD, Satouris P, et al. - Researchers investigated the reasons for the observed increased risk of certain acute metabolic disorders in patients with Addison's disease (AD) and comorbid type 1 diabetes mellitus (T1DM) vs patients with one of these conditions only. Between 2000 and 2017, all attendances for acute illness by AD patients at the emergency department of a Sydney hospital have been reviewed. Physiological parameters and illness management strategies have been contrasted between AD patients, those with T1DM and AD combined, and a control group of patients with T1DM. AD patients with T1DM report a higher incidence of adrenal crisis (AC) and hypoglycaemia than patients with non-diabetic AD, and a lower incidence of hyperglycaemia than patients with T1DM. This knowledge can be useful in treating patients with T1DM and AD about prevention of AC and hypoglycaemia.