Vakilzadeh N, et al. - In healthy overweight subjects, researchers evaluated the impact of acute hyperglycemia on renal tissue oxygenation, according to blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) measurement. For this investigation, they performed BOLD-MRI before and quickly after the intravenous administration of 0.15 g/kg of glucose in a 20% solution under standard hydration and fasting conditions. Investigators found that the mean R2* values in all layers of the kidney decreased significantly, regardless of glucose intolerance. According to findings, acute hyperglycemia may reduce the R2* signal in humans, implying an acute increase in renal tissue oxygenation. This observation's precise mechanism remains unknown, and whether this phenomenon also occurs in patients with diabetes warrants further study.