Belhadjer Z, Méot M, Bajolle F, et al. - As SARS-CoV-2 infection is typically minimally symptomatic in children, researchers here reported a series of febrile pediatric patients with acute heart failure potentially linked with SARS-CoV-2 infection and the multisystem inflammatory syndrome in children (MIS-C) as defined by the US Centers for Disease Control. Over a 2-month period contemporary with the SARS-CoV-2 pandemic in France and Switzerland, they identified 35 children [median age at admission: 10 years (range 2-16 years)] for inclusion in the study. Co-morbidities, including asthma and overweight, were present in 28%. Prominent gastrointestinal symptoms were reported in these cases. One third of the cases had left ventricular ejection fraction < 30%; there were 80% requiring inotropic support with 28% treated with ECMO. Cytokine storm (interleukin 6 median 135 pg/mL) and macrophage activation (D-dimer median 5284 ng/mL) were suggested by the inflammation markers. Elevation of mean brain natriuretic peptide was noted (5,743 pg/mL). Per these observations, an acute cardiac decompensation due to severe inflammatory state following SARS-CoV-2 infection may occur in children (multisystem inflammatory syndrome in children - MIS-C). They suggest treatment with immune globulin to be possibly linked with recovery of left ventricular systolic function.