Schmitt FCF, et al. - Given that acute fibrinolysis shutdown has recently been described to be a crucial component of initial hypercoagulability in critically ill patients, researchers determined the underlying pathomechanisms, specific temporal kinetics, and outcome relevance in patients with sepsis. This study sample consisted of 90 participants: 30 with septic shock, 30 surgical controls, and 30 healthy volunteers. As evaluated by viscoelastic point-of-care testing, fibrinolysis shutdown occurred early in sepsis. Findings suggested that early plasminogen activation inhibition may lead to acute fibrinolysis shutdown with improved clot stability, and may be related to increased morbidity and mortality in septic patients.