Narayan RN, et al. - In this retrospective case series, researchers characterized three fulminant cases of acute disseminated encephalomyelitis (ADEM) complicated by increased intracranial pressure correlated with the presence of the anti-myelin oligodendrocyte glycoprotein (MOG) antibodies. Findings suggested that high intracranial pressure linked to ADEM in the presence of MOG antibodies can lead to cerebral edema, herniation, prolonged hospital stay, and long-term disability. Investigators found that increased intracranial pressure that complicates the MOG antibody—related ADEM is a distinctive finding in the cases. This can complicate ADEM's clinical picture and result in elevated morbidity. In selected cases with persistent seropositivity, long-term immunosuppression is warranted.