Traicu A, et al. - In this exploratory study involving 513 children with ADHD (aged 6-12 years), researchers examined whether the neurocognitive response to methylphenidate (MPH) in the Conners Continuous Performance Test (CPT) is correlated with the change in systolic blood pressure (sBP) after acute MPH administration. Participants with a clinically meaningful sBP increase of at least 5 mmHg (n = 191) displayed improvement in the CPT-overall index score by 4.8 points, compared with an improvement of only 0.6 points in participants with sBP decline by at least 5 mmHg (n = 121). Observations thereby suggested a correlation of higher increases in sBP with larger improvement in attention as well as with better clinical response.