Mace P, Mancini J, Gorincour G, et al. - A systematic literature search was conducted in MEDLINE and COCHRANE from 2009 to April 2020 to evaluate and compare the accuracy of qualitative and quantitative cranial sonographic markers at 11–14 weeks of gestation for the detection of open spina bifida (OSB) and other posterior brain defects (oPBD). Studies evaluating the diagnostic accuracy of quantitative and/or qualitative ultrasound signs to predict OSB and oPBD were involved. The meta-analysis comprised of 23 studies. The overall sensitivity of cranial sonographic markers was 76.7% and specificity was 97.5% for oPBD screening. The qualitative approach showed greater specificity, so this would seem to be more suitable for daily screening, as a first‐line tool, while the quantitative approach should be reserved for an expert ultrasound.