Ondersma SJ, et al. - In this diagnostic accuracy study involving 1220 participants, researchers compared 5 existing instruments for ability to identify illicit drug, opioid and alcohol use, under privacy expectations consistent with applied practice and utilizing a gold standard incorporating toxicological analysis. Instruments incorporated the Substance Use Risk Profile—Pregnancy (SURP-P), CRAFFT (acronym for five-item screener with items related to car, relax, alone, forget, friends and trouble), 5Ps (parents, peers, partner, pregnancy, past), Wayne Indirect Drug Use Screener (WIDUS) and the National Institute on Drug Abuse (NIDA) Quick Screen. Data reported that the 5Ps showed high sensitivity (0.80–0.88) but low specificity (0.35–0.37). According to this prospective cross-sectional screening accuracy study, of 5 screening instruments for substance use in pregnancy tested (Substance Use Risk Profile—Pregnancy (SURP-P), CRAFFT, 5Ps, Wayne Indirect Drug Use Screener (WIDUS) and the National Institute on Drug Abuse (Quick Screen), none exhibited high sensitivity and high specificity, and area under the curve was low for almost all measures.