Pei Y, Shi M, Song J, et al. - Researchers sought to determine the role of the absolute number of circulating leukemic cells in early bleeding events in patients suffering from acute promyelocytic leukemia (APL). Participants were 149 patients newly diagnosed with APL, from whom clinical and laboratory characteristics were collected using medical records and retrospectively examined. In multivariate logistic regression analysis, the absolute number of leukemia cells was identified as an independent risk factor for significant bleeding events in APL cases. According to receiver operating characteristic curve analysis, significant bleeding events in APL were predicted by circulating leukemic cells at a cut-off value of 2.59× 10 ⁹ /L. Findings demonstrate great clinical value of circulating leukemic cell content for predicting early bleeding events in APL cases, particularly in non-high-risk APL.