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Abnormal fasting glucose increases risk of unrecognized myocardial infarctions in an elderly cohort

Journal of the American Geriatrics Society Jan 16, 2019

Stacey RB, et al. - In this study involving a cohort of individuals aged ≥ 65 years, researchers evaluated glucose levels as a risk factor for unrecognized myocardial infarctions (UMIs). Participants were examined for fasting glucose levels (N=4,355; normal fasting glucose [NFG], n=2,041; impaired fasting glucose [IFG], n=1,706; DM, n=608) and were followed-up over a mean duration of 6 years. Participants with prior coronary heart disease or UMI on initial electrocardiography were excluded from study enrollment. A total of 459 incident UMIs (NFG, n=202; IFG, n=183; DM, n=74) were reported during follow-up. An episode of UMI was slightly more likely to occur in those with IFG vs those with NFG, as well as more likely to be experienced by those with DM vs those with NFG. A UMI was no more likely to occur in those with IFG than those with NFG after adjustment HR for UMI in IFG, whereas those with DM were more likely than those with NFG to experience a UMI. There was no statistically significant association of 2-hour oral glucose tolerance test with UMI. Overall, UMI was predicted by fasting glucose status, particularly in the diabetic range.

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