Fond G, Micoulaud-Franchi JA, Faugere M, et al. - Researchers examined the prevalence of major depression, antidepressant prescription and remission under antidepressant in a stabilized population of schizophrenia (SZ) and unipolar disorder (UD) patients consulting in a daily hospital. In addition, they assessed the value of C-reactive protein (CRP) as a marker of major depression and remission under antidepressant in these SZ and UD populations. A CRP blood level ≥ 3 mg/L defined abnormal CRP. The Calgary Depression Rating Scale score was used to determine depressive symptoms. They analyzed 411 patients (272 SZ and 139 UD). Major depression was diagnosed in 171 (41.6%) (74 (27.2%) for SZ and 97 (69.8%) for UD). Antidepressant treatment was reported in 86 SZ (31.6%) and 119 UD (85.6%) patients.As per findings, major depression is frequent in SZ patients and increased CRP levels are correlated with non-remission under antidepressants in this population. This emphasizes the utility of anti-inflammatory strategies in this specific population.