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Abnormal activity of neck inspiratory muscles during sleep as a prognostic indicator in chronic obstructive pulmonary disease

American Journal of Respiratory and Critical Care Medicine Feb 19, 2020

Redolfi S, Grassion L, Rivals I, et al. - Given increased activity of neck inspiratory muscles has been observed as a compensatory response to hyperinflation-associated diaphragmatic dysfunction among patients with chronic obstructive pulmonary disease (COPD) and as a result of the persistence of this activity during sleep, sleep-related hypoventilation could be attenuated and sleep and clinical outcomes could be influenced negatively, so, researchers performed this study with patients with COPD recovering from severe exacerbations (ie, necessitating hospitalization) in order to determine the persistence of neck-muscle activity during sleep as well as its influence on sleep quality and recurrence of exacerbations. The participants were 29 patients in total, with median age of 71 years, body mass index, 24, FEV1% predicted, 37, and BODE [body mass index, airflow obstruction, dyspnea, and exercise] index, 6. Findings revealed that these patients frequently showed sleep-related neck-muscle activity, which appeared to negatively influence sleep quality and prognosis; thus, its identification might lead to improved COPD management after a severe exacerbation.
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