Kim NH, et al. - In this cross-sectional study, researchers ascertained if waist circumference (WC) is correlated with colorectal neoplasia (CRN) risk, independent of body mass index (BMI). The study sample consisted of 154,552 asymptomatic examinees who had a colonoscopy for a health check-up. CRN prevalence rates in subjects in WC quartiles 1, 2, 3, and 4 were15.6%, 18.1%, 20.4%, and 22.0% among men and 7.8%, 9.4%, 12.2%, and 15.8% among women, respectively. In both men and women, WC and BMI were independent risk factors for overall CRN and nonadvanced CRN. Findings suggested an association of abdominal obesity with an increased risk of advanced CRN, independent of overall obesity (BMI) in men. In women, there was no association between WC and BMI with the risk of advanced CRN. Compared with overall obesity in men, abdominal obesity was more strongly predictive of advanced CRN.