Pontillo C, et al. - An analysis was designed to examine the performance of the urinary proteome-based classifier CKD273, compared with urinary albumin excretion (UAE), in a number of different narrow ranges of chronic kidney disease (CKD) severity, with each range separated by an estimated glomerular filtration rate (eGFR) of 10 mL/min/1.73 m2. Urinary peptides, as combined in the CKD273 classifier, allowed the detection of progressive CKD at early stages, a point where therapeutic intervention was more likely to be effective. On the other hand, late-stage disease, where the irreversible damage of the kidney was already present, was better detected by UAE.