Gilliam FG, Black KJ, Carter J, et al. - Researchers assessed the comparative effectiveness of sertraline and cognitive behavior therapy (CBT) for depression, quality of life, seizures, and adverse treatment effects in this investigation. They randomized 140 adult outpatients with epilepsy and current major depressive disorder to sertraline or weekly CBT for 16 weeks. They found that the difference in occurrence of generalized tonic–clonic seizures between groups was 0.3%, and noted a potential association of suicide risk with persistent depression at the final assessment—but not seizures or sertraline. Depression remitted after sertraline or CBT in just over one-half of individuals. Despite the epilepsy-related complex psychosocial disability, improving depression may benefit patient quality of life. Inhibition of serotonin reuptake in those with epilepsy, however, did not appear to boost seizures or suicidality.