Noori VJ, et al. - An up-to-date summarization of available Food and Drug Administration-approved vascular closure devices (VCDs) was provided. In addition, current evidence comparing individual devices with one another and with manual compression (MC) was analyzed. Findings revealed a significant improvement in patients' comfort and satisfaction as well as in time to hemostasis and ambulation after percutaneous vascular procedures in association with VCDs. This meta-analysis suggested VCDs and MC as comparable regarding complication rates, safety and efficacy, and outcomes. VCDs, with a low incidence of major complications and high success rates, seems convenient for the practitioner and facilitates turnover of patients. Compared to MC, VCDs exhibited a small risk of infectious and thrombotic complications that may increase. Balancing the goals of comfort of the patient, resources of the staff, and early ambulation against periprocedural and anatomic risk factors (ie, individualize use of VCDs to specific clinical scenarios) is recommended.