Narendran P, Tomlinson C, Beese S, et al. - Robust evidence supporting that interventions to improve glucose control preserve β-cell function in new onset type 1 diabetes are lacking, although this largest comprehensive review of randomised controlled trials (RCTs) in this area was hindered by low-quality evidence and inconsistent reporting of studies.

• Eligible RCTs (which included newly diagnosed patients with type 1 diabetes, any intervention to improve glucose control and at least 1 month of follow-up) were identified from MEDLINE, Embase, Cochrane CENTRAL, ClinicalTrials.gov and WHO International Clinical Trials Registry.

• This meta-analysis included 28 studies comprising 1,662 participants, categorized by intervention into six subgroups (alternative insulins, subcutaneous and intravenous insulin delivery, intensive therapy, glucose sensing, adjuncts).

• In only three studies, an improvement occurred in glucose control as well as in β-cell function.

• These interventions involved intensive insulin therapy and use of an alternative insulin.