George Stojan, et al. - A spatial-time cluster analysis of the Hopkins Lupus Cohort was conducted to evaluate potential clusters of SLE organ-specific flares and their relation to temperature fluctuations and fine particulate matter pollution. In the analysis, researchers recruited a total of 1,261 individuals who fulfilled the SLICC classification criteria for SLE and who had reported home addresses. The study evaluated rash, joint involvement, serositis, neurologic, pulmonary, renal, and hematologic activity on a 0-3 visual analogue scale. Further, they applied regression models for cluster adjustment and included individual, county-level, as well as environmental variables. The first space-time clusters of lupus organ-specific disease activity were described. The study distinguished seasonal, as well as multi-year cluster patterns, differing in extent and location for the various organ-specific flare types.