Olsson LM, et al. - This study was meant to determine the association and function of the missense single nucleotide polymorphism (SNP), rs201802880 (here denoted NCF1-339) in NCF1 with systemic lupus erythematosus (SLE). Evidence displayed that a genetically controlled reduced production of reactive oxygen species (ROS) increases the risk of developing SLE. These findings confirmed the hypothesis that ROS regulate chronic autoimmune inflammatory diseases.