Vachiramon V, Namasondhi A, Anuntrangsee T, et al. - It appears that ultraviolet B (UVB)-induced hyperpigmentation can be safely and effectively treated with alexandrite 755-nm picosecond and Nd:YAG (neodymium-doped yttrium aluminum garnet) 1064-nm picosecond lasers. Seemingly, the 755-nm picosecond laser treatment is better than 1064-nm picosecond laser treatment in terms of outcomes, especially for FPT4 (Fitzpatrick skin type).

• A randomized, single-blinded study to assess the efficacy of alexandrite 755-nm picosecond and Nd:YAG 1064-nm picosecond lasers for the treatment of UVB-induced hyperpigmentation among Asians.

• Three spots with UVB-induced hyperpigmentation were allocated into 755-treated, 1064-treated, and control sites; patients (n=20) underwent weekly laser treatments for five sessions.

• The mean lightness index (L*) improved significantly with 755-nm and 1064-nm picosecond lasers vs the control site, which initiated at Day 49 and Day 77, respectively.

• At Day 105, higher mean L* of the 755-nm-treated site was evident than that of the 1064-nm–treated site.

• The 1064-nm picosecond laser initially offered better mean L*, physician's visual analog scale (VAS) and patient satisfaction, but an inversion of the mean L* and VAS was observed at Day 49, whereas the mean patient satisfaction was observed at Day 77.