De Padova MP, et al. - Authors tested the effectiveness and tolerability of a topical product containing 2,4,6-octatrienoic acid and urea for the treatment of hyperkeratotic Actinic keratosis (AK) lesions. Findings suggested safety and efficacy of the application of a topical combination of 2,4,6-octatrienoic acid and urea twice daily for 60 consecutive days for hyperkeratotic AK lesions. In 57.5% of the subjects, complete elimination of lesions had occurred at T1, and at T2 in 82.5%. They did not report any side effects.