Uwaezuoke SN, Ndu IK, Eneh CI, et al. - Researchers conducted this parallel-group randomized controlled trial (RCT) to determine and compare the effectiveness of a short course of oral ranitidine (an H₂ blocker) and a probiotic in the treatment of toddler’s diarrhea. Forty patients were sequentially enrolled who met the eligibility criteria. Twenty patients were randomly assigned to the oral ranitidine group, ten patients to the probiotic group, and ten patients to the placebo group. The authors discovered that a daily dose of oral ranitidine successfully relieved the symptoms of toddler’s diarrhea on the tenth day of treatment. Substantial reductions in daily stool frequency and improvement in stool consistency also occurred on the fifth day of treatment. Patients remained symptom-free 60 days after the intervention had stopped. Overall, the authors concluded that oral ranitidine is more effective in reducing stool frequency and normalizing stool consistency in toddler’s diarrhea than probiotics. Multi-center trials with appropriate study designs were recommended to confirm and validate this finding.