Kelava I, et al. - Researchers here reported the case of a 59-year-old male patient with final diagnosis of temporal bone myxoma. His presenting complaints were a sensation of fullness in his right ear, intermittent otorrhea, and impaired hearing. He had medical history of undergoing myringoplasty on the right ear in 1973. No ear-related complaints were reported after undergoing the procedure until 8 months prior to this visit. Obstructive mass was detected in the right ear canal in otoscopic examination. Severe mixed hearing loss on the right ear was indicated in a pure tone audiogram. In multislice CT, they detected osteodestructive mass obliterating external ear canal, tympanum, and mastoid with bone erosion of the lateral wall of epitympanum and tegmen tympani toward the middle cranial fossa. In MRI, they noted a heterogeneous expansive mass with homogeneous opacification on postcontrast view in epitympanum and mastoid as well as erosion of tegmen tympani. Intraoperatively, they identified tumor mass in the external ear canal, mastoid, and tympanum. Further, they noted a large bone defect of tegmen tympani toward the middle cranial fossa. Dehiscence of the lateral semicircular and facial canal were observed, along with complete erosion of hearing ossicles. Radical tympanomastoidectomy was performed to remove the tumor completely. The patient had an uneventful postoperative recovery, with no signs of facial nerve palsy. They suggest performing a histological examination and immunohistochemical staining for a definitive diagnosis. As myxomas are generally insensitive to radiation therapy, surgical resection is the treatment of choice.