Cobo T, Aldecoa V, Holeckova M, et al. - Researchers conducted this retrospective observational study to validate the automated immunoassay as a quantitative method to measure amniotic fluid (AF) interleukin (IL)-6 in women with preterm labor (PTL) and to assess the diagnostic performance of AF IL-6 alone and as part of a multivariable predictive model to predict spontaneous delivery in 7 days with this automated method. The sample consisted of women with PTL below 34 weeks who underwent amniocentesis to rule out microbial invasion of the amniotic cavity. Although both analytical methods were similar for measuring AF IL-6 concentrations in women with PTL, the Cobas immunoanalyzer offered a rapid diagnosis of intra-amniotic inflammation within minutes. The predictive model performed well in terms of identifying women at high risk of spontaneous delivery within 7 days.