Makrides M, Best K, Yelland L, et al. - Through a multicenter, double-blind, randomized trial of women who were pregnant with single or multiple fetuses (n = 5,517), researchers ascertained the role of n−3 long-chain polyunsaturated fatty acids supplementation in pregnancy and preterm delivery. In the case of 61 of 2,734 pregnancies in the n−3 group and 55 of 2,752 pregnancies in the control group, the occurrence of early preterm delivery was noted and the between-group variation was not important. No notable variations between the groups in the incidence of interventions in postterm (> 41 weeks of gestation) deliveries, in adverse events, or in other pregnancy or neonatal outcomes were noticed, except that a higher percentage of infants born to women in the n−3 group vs control group were very big for gestational age at birth. Percentages of severe adverse events did not vary among the groups. Insignificant gastrointestinal disturbances were more usually stated in the n−3 group vs the control group. Thus, n−3 long-chain polyunsaturated fatty acids supplementation given from early pregnancy (< 20 weeks of gestation) until 34 weeks of gestation did not lead to a lower incidence of early preterm delivery or a greater incidence of interventions in postterm deliveries in comparison with control.