Zomar BO, Vasarhelyi EM, Somerville LE, et al. - A randomized controlled trial was conducted to ascertain the cost-utility of patient-specific instrumentation (PSI) compared with standard of care (SOC) instrumentation for total knee arthroplasty (TKA) in an obese population. Researchers randomized patients with body mass index greater than 30 with osteoarthritis and undergoing primary TKA to SOC or PSI. They conducted cost-utility and cost-effectiveness analyses from public health care payer and societal perspectives. They enrolled 173 patients in the analysis with 86 patients assigned randomly to PSI and 87 to SOC. The data imply that widespread adoption of PSI may not be economically attractive or clinically indicated. There is a need for the future evaluations to compare long-term clinical outcomes and radiographic alignment between the groups.