Carney RM, et al. - In depressed patients with or at high risk for coronary heart disease (CHD), researchers investigated how the response to sertraline would be influenced by adding eicosapentaenoic acid (EPA), an omega-3 fatty acid. They randomized 144 eligible patients to receive either 50 mg/day of sertraline and 2 g/day of EPA or 50 mg/day of sertraline and corn oil placebo capsules for 10 weeks. As per outcomes, these patients achieved no greater improvement in depressive symptoms when sertraline was augmented with 2 g/day of EPA for 10 weeks vs corn oil placebo.