A randomized, open-label, multicentre, parallel-controlled study comparing the efficacy and safety of biphasic insulin aspart 30 plus metformin with biphasic insulin aspart 30 monotherapy for type 2 diabetes patients inadequately controlled with oral antidiabetic drugs: The Merit study
Diabetes, Obesity and Metabolism Jul 13, 2018
Guo L, et al. - In this 16-week, prospective, randomized, open-label, multicenter, parallel-controlled study, researchers intended to confirm non-inferiority of biphasic insulin aspart 30 (BIAsp 30) + metformin to BIAsp 30 monotherapy in lowering glycated hemoglobin (HbA1c) in Chinese subjects with inadequately controlled type 2 diabetes on oral antidiabetic drugs. For this analysis, patients aged 18-79 years with HbA1c ≥ 7% were randomized to BIAsp 30 + metformin (n=130) or BIAsp 30 (n=127). It was observed that BIAsp 30 plus metformin was non-inferior to BIAsp 30 in reducing HbA1c safely.
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