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A randomized controlled trial of amnioexchange for fetal gastroschisis

BJOG: An International Journal of Obstetrics and Gynaecology May 03, 2019

Luton D, et al. - Via performing this prospective, interventional, randomized study including 64 pregnant women with a fetus carrying a gastroschisis, researchers examined if amnioexchange procedure benefits fetal gastroschisis. Comparison of, in utero, amnioexchange with a sham procedure was done. In both arms, the protocol included steroid injections at 30 weeks and the use of post-natal minimal enteral feeding. The group showed no significant differences in pregnancy outcome or complications. They identified a clear correlation between bile acid and both ferritin and IL1β when the relation between digestive compounds and amniotic fluid inflammatory markers was studied. These findings do not support amnioexchange as an option for fetal care in humans.
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