Scaratti C, et al. - Given a higher tendency than others to relapse and need further structured treatments after structured withdrawal among some patients with chronic migraine and medication overuse headache (CM with MOH), researchers investigated similarities and differences between frequent relapsers (FRs) and non-frequent relapsers (NFRs) by evaluating their point of view, perceptions, and perspective of their subjective experience with relapse. They interviewed 16 patients (13 women; mean age of 53); 7 were classified as FRs. As per results, aspects common to both FRs and NFRs were issues connected to the dilemma between disclosing, concealing and the feelings of isolation around MOH, the idea of being addicted to medication, presence of anxiety, and the attempt to use non-pharmacological therapies as an alternative to medication. The patients had peculiar aspects including causal attribution (FRs attributed headache to uncontrollable factors); future expectations at the time point of withdrawal (FRs were generally resigned); high-performance functioning (FRs believed they are “forced” to reach high levels of performance as a consequence of others’ inability); coping strategies (FRs tended to “passively accept” problems and showed avoidance-related behaviors). Moreover, FRs were usually less aware of their problems and described depressive symptoms more frequently.