Ząbczyk M, et al. - As left ventricular thrombus (LVT) is associated with a hypercoagulable state and occurs most frequently following myocardial infarction (MI), researchers investigated if blood prothrombotic alterations predispose to LVT formation, its recurrence, and subsequent cerebrovascular events via evaluating 58 patients with a history of LVT unrelated to recent MI or LV ejection fraction < 25% and 58 well-matched control participants. Following 3-6 months of anticoagulant treatment, plasma clot permeability, fibrinolytic efficiency, thrombin generation, and endothelial markers were determined. Observations revealed that patients who develop LVT not related to MI and those prone to its recurrence had a persistent prothrombotic state involving enhanced thrombin generation, hypofibrinolysis, and formation of more compact fibrin clots.