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A prospective study of nut consumption and risk of primary hepatocellular carcinoma in the U.S. women and men

Cancer Prevention Research May 23, 2019

Sui J, et al. - Among participants from the Nurses’ Health Study (n=88,783 women) and the Health Professionals Follow-up Study (n=51,492 men), researchers prospectively assessed hepatocellular carcinoma (HCC) risk in relation to nut consumption. Using validated food-frequency questionnaires, they evaluated nut intake among participants every 4 years. After adjusting for HCC risk factors, they estimated multivariable HRs and 95% CI via Cox proportional hazards regression models. Participants were followed-up for an average of 27.9 years. Overall, they did not identify any strong link between nut consumption and HCC risk. However, there was evidence suggestive of an inverse link with tree nut intake. Additionally, inverse links with the intake of walnuts, peanuts, and peanut butter were observed; however, these links were nonsignificant.

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