A prospective study evaluating the effects of SSRI exposure on cardiac size and function in newborns
Neonatology Mar 09, 2019
Ansah DA, et al. - In this investigation, researchers tested the premises that in utero selective serotonin reuptake inhibitor (SSRI), antidepressants prescribed in 10% of pregnancies in the USA, exposure would result in reduced left ventricular dimensions and cardiac function on echocardiography immediately after birth. In order to assess cardiac size and function, 20 term infants with and 21 term infants without in utero exposure to SSRIs underwent echocardiograms. According to findings, an association was found between in utero exposure to SSRIs and ventricular size in infants. No differences in cardiac function were observed. Importantly, neither maternal conditions nor infant birth weight, body surface area, or gestational age differed. Given the increasing use of SSRIs during pregnancy and the importance of early life programming for future cardiovascular health, more extensive studies need to be completed to determine whether exposure to SSRI in utero affects ventricular size.
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