A prospective randomized trial of intravenous ketorolac vs acetaminophen administered with opioid patient-controlled analgesia in gynecologic surgery
Gynecologic Oncology Oct 18, 2019
Rakowski JA, Holloway RW, Ahmad S, et al. - Through a prospective, randomized trial of acetaminophen (A) 1-g intravenous (IV) every 6-h or ketorolac (K) 15-mg IV every 6-h from postoperative day 1–3 supplementary to an opioid patient-controlled analgesia (PCA) for individuals who underwent benign or malignant gynecologic laparotomy procedures (n = 100, 55 benign gynecologic laparotomies and 45 cancer-related laparotomies), researchers ascertained which non-narcotic analgesic, acetaminophen (Ofirmev) or ketorolac (Toradol), gave superior postoperative pain control when combined with an opioid PCA pump and to compare the rates of ileus, postoperative bleeding, transfusions, and length-of-hospitalization. Through VAS pain scales and PCA pumps, both intravenous ketorolac and acetaminophen gave comparable postoperative analgesia and total usage of morphine, respectively. Compared with acetaminophen, the use of ketorolac with Dilaudid PCA was related to less dependency on Dilaudid and a faster return of bowel function, nevertheless, length of stay and transfusion rates were not distinctive.
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