Jennings JM, et al. - A total of 29 patients who underwent simultaneous bilateral total knee arthroplasty (TKA) were recruited in a prospective, randomized blinded study by the researchers in order to assess whether closed suction drain (CSD) use impacted the restoration of quadriceps strength and to investigate the influences of drain use on secondary outcomes: quadriceps activation, intra-articular effusion, bioelectrical measure of swelling, range of movement (ROM), pain, and wound healing complications. For primary or secondary outcomes, no marked differences were ascertained among limbs before surgery. At postoperative day two, two weeks, six weeks, or three months, no significant variations in quadriceps strength were observed between CSD and subcutaneous drain (SCDRN) limbs. In the CSD limb, the secondary outcome of knee extension ROM was markedly greater in comparison with the SCDRN at two weeks post-surgery, however, this difference was not seen at all other intervals. Secondary outcomes of quadriceps activation, intra-articular effusion, lower limb swelling, and pain were not noticed to differ markedly at any time point post-surgery. Hence, no impact on quadriceps strength, quadriceps activation, intra-articular effusion, lower limb swelling, ROM, or pain by the use of CSD during TKA was ascertained. Furthermore, in primary uncomplicated TKA, these outcomes had limited drain use by the authors.