Lee DW, et al. - Among 69 consecutive patients undergoing transurethral prostate resection or holmium laser resection of the prostate under spinal anesthesia, researchers assessed the response to sedation with an α2receptor agonist in those using long-term selective α1 blockers. Study participants were divided into two groups: those who did not receive α1 blockers (group N; n=37) and those who received tamsulosin for at least 1 month before the study (group T; n=32). Bispectral index scores, Modified Observer’s Assessment of Alertness/Sedation scale scores, heart rate, and mean blood pressure levels were obtained under sedation using dexmedetomidine for 30 minutes during surgery. The researchers found that mean blood pressure levels 15 minutes following the first loading dose injection of dexmedetomidine were the only significant difference between the groups. They suggested that, for benign prostatic hyperplasia patients using tamsulosin, it may be appropriate to use α2 agonists during surgery, with no need for dose modification.