A prospective multicenter study on the evaluation of antimicrobial resistance and molecular epidemiology of multidrug-resistant Acinetobacter baumannii infections in intensive care units with clinical and environmental features
Annals of Clinical Microbiology and Antimicrobials Jul 10, 2019
Boral B, et al. - Researchers conducted a multicenter prospective study at 10 different hospitals from five geographical regions of Turkey in terms of the demographic and clinical traits of patients over a 6-month period to assess antimicrobial resistance and clonal distribution of multidrug-resistant (MDR) clinical and environmental A. baumannii isolates obtained from the intensive care units of these hospitals. This study included a total of 164 clinical and 12 environmental MDR A. baumannii isolates. Among 164 patients, a mortality rate of 58.5% was observed. Diabetes mellitus, liver failure, the use of chemotherapy and previous use of quinolones were identified as the risk factors for mortality. The most efficacious antibiotic against A. baumannii infections is still colistin. In Turkey, the gene blaOXA-23 has become the most prevalent carbapenemase. They identified no diversity in the distribution of invasive A. baumannii isolates from different regions of Turkey. Revision of infection control measures at medical centers is recommended to reduce the MDR A. baumannii infections across the country.
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