Menchón JM, Real E, Alonso P, et al. - In order to assess the safety profile of deep brain stimulation (DBS) for psychiatric disorders, researchers conducted a prospective, open-label, interventional multi-center study including 30 patients receiving electrical stimulation with DBS electrodes bilaterally implanted in the anterior limb of the internal capsule. Adverse events (AEs) occurred in all patients (195 in total); of these, majority were mild (52% of all AEs) or moderate (37%). A total of 36 serious adverse events (SAEs) occurred in 16 patients (eight of them occurred in one single patient); transient anxiety and affective symptoms worsening were mainly reported (20 SAEs). Regarding efficacy measures, they reported a reduction of 42% in Yale-Brown Obsessive-Compulsive Scale score at 12 months and the responder rate of 60%. In addition, the cases exhibited improvements in Global Assessment of Functioning, Clinical Global Impressions Scale, and EuroQol group-5 Dimensional index scores were also observed. This study suggests that in a severely treatment-resistant population, the potential benefits may outweigh the potential risks of DBS.