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A prospective cohort study that examined acute kidney injury and kidney outcomes, cardiovascular events and death informs on long-term clinical outcomes

Kidney International Jul 27, 2020

Ikizler TA, Parikh CR, Himmelfarb J, et al. - Given that a link of acute kidney injury (AKI) with excess risks of mortality, kidney disease progression as well as cardiovascular events has been documented, but earlier investigations have crucial limitations, so, to further investigate this, this study was undertaken wherein experts prospectively examined adults surviving three months and more following hospitalization with or without AKI. All participants underwent evaluations of renal function prior to (eGFR; estimated glomerular filtration rate) and at three months and yearly (eGFR and proteinuria) following the index hospitalization. This study involved 769 AKI (73% Stage 1, 14% Stage 2, 13% Stage 3) as well as 769 matched non-AKI adults. Among these groups, AKI was shown to be related to higher adjusted rates of incident chronic kidney disease (CKD), CKD advancement, heart failure events and all-cause mortality. Overall, essential prognostic information for long-term clinical results can be gained via evaluating kidney function recovery and proteinuria status three months post-AKI.

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