Bolli GB, et al. - In this post-hoc analysis, researchers assessed the risk of nocturnal hypoglycemia with insulin glargine 300 U/mL (Gla-300) vs glargine 100 U/mL (Gla-100) using data pooled from three trials in which participants with type 2 diabetes (T2DM) used only basal insulin (EDITION 2, 3 and JP 2) without the confounding effects of the prandial insulin used in EDITION 1. Hypoglycemia was analyzed at night using a predefined 0:00–5:59 AM nocturnal interval and three expansions. According to findings, hypoglycemic events specifically induced by basal insulin were reported most often between 6:00 a.m. and 8:00 a.m., with varied breakfast time, but most often between 7:00 a.m. and 8:00 a.m. Broader observation windows for hypoglycemia during a nocturnal/fasting period past 6:00 a.m. allow for the identification of more affected persons and more events caused by basal insulin.Lower incidence and rate of nocturnal hypoglycemia with Gla-300 vs Gla-100 was confirmed using all analysed time windows, showing a consistently reduced risk with Gla-300 compared to Gla-100.