Rogers VE, et al. - Among 33 children (age 4–12 years) and adolescents (age 13–19 years) during hospitalization, researchers ascertained if a sleep intervention compared with standard of care (SOC) was successful in preserving nighttime sleep in children with central nervous system cancers hospitalized for high-dose chemotherapy (HDCT) and autologous stem cell rescue, and investigated connections between sleep and fatigue during treatment. The data presented in this work showed a multicomponent sleep intervention modestly preserved nighttime sleep duration in this sample of children undergoing HDCT, although overall sleep was poor in both groups. Sleep is an integral part of health and can have an impact on the outcomes of children receiving HDCT. Further investigation into sleep preservation methods is warranted in children undergoing intensive cancer therapy.