Carabias LA, et al. - Researchers evaluated the pharmacokinetics, safety, and tolerability of Risperidone ISM multiple intramuscular injections once every 4 weeks in patients with schizophrenia. After drug administration, Risperidone ISM achieved therapeutic levels from the first hours. Throughout the 4-week dosing period, it gave a sustained release over multiple intramuscular injections and was appeared safe and well tolerated.