Greenberg RG, Wu H, Maharaj A, et al. - This was a retrospective cohort study of infants receiving clindamycin prior to postnatal day 121 who were discharged from a Pediatrix Medical Group neonatal intensive care unit (1997–2015), researchers intend to evaluate the association between clindamycin exposure and adverse events, as well as antibiotic effectiveness in infants. In a total of 4,089 infants, who received clindamycin at a median dose of 15 mg/kg/d. Clearance increased with older gestational age. It was found that there was no association among higher clindamycin exposure and with increased odds of death or nonlaboratory adverse events. In infants, when large-scale trials were not possible, the utility of pharmacokinetic models joined with available electronic health record data offers a valuable, cost-effective strategy for analyzing the safety and efficacy of drugs.