James PT, Jawla O, Mohammed NI, et al. - Through a randomized controlled trial in 290 nonpregnant women in the rural Gambia, researchers examined the efficiency of a novel nutritional supplement designed to improve one-carbon-related nutrient status by decreasing plasma homocysteine and evaluated its potential future use in preconception trials. The drink powder and United Nations Multiple Micronutrient Preparation [UNIMMAP] decreased mean plasma homocysteine by 23.6% and 15.5%, respectively, in comparison with the controls, at the endline. On the contrary to UNIMMAP, the drink powder decreased mean homocysteine by 8.8%. No impact of either intervention on blood pressure or pulse compared with the control at the endline was noted. In both intervention arms, self-reported adverse events (AEs) were comparable. Two serious AEs were listed over the trial term, both in the drink powder arm, but concluded to be unrelated to the intervention. Hence, to prognosticate offspring DNA methylation, dietary supplements could affect metabolic pathways as exhibited in former studies. Both supplements decreased homocysteine efficiently and continued to be potential candidates for prospective epigenetic trials in pregnancy in the rural Gambia.